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KMID : 0359020080360040206
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Korean Journal of Gastrointestinal Endoscopy
2008 Volume.36 No. 4 p.206 ~ p.212
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The Effects of Flumazenil on the Recovery Time and Satisfaction of the Use of Sedative Endoscopy with Midazolam
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Kim Dae-Kyoum
Jung Hwoon-Yong
Ko Hyo-Mi
Jo Ji-Yun
Kim Seog-Gyun
Lee Don
Chang Hye-Sook
Song Hye-Kyung
Lee Hyun-Ju
Chung Eun-Ju
Park Hye-Won
Kim Jin-Ho
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Abstract
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Background/Aims: Treatment with flumazenil results in rapid reversal from sedation. In addition, the use of flumazenil
can prevent accidents or memory loss after endoscopy. This study was conducted to evaluate the role of flumazenil according to dose.
Methods: A total of 150 consecutive outpatients were randomly allocated into three groups: patients given normal saline (control group), patients given 0.25 mg flumazenil (0.25 mg flumazenil group) and patients given 0.5 mg flumazenil (0.5 mg flumazenil group). Flumazenil or normal saline was injected 10 minutes after the completion of endoscopy. We evaluated the recovery time, time to discharge, patient satisfaction, and memory loss after discharge.
Results: The control group consisted of 44 subjects, the 0.25 mg flumazenil group consisted of 46 subjects and the 0.5 mg flumazenil group consisted of 45 subjects. The recovery time was significantly shorter in the two flumazenil groups as
compared to the control group (28.5±15.0 min, 13.8±3.7 min, 12.4±1.7 min for the control group, 0.25 mg flumazenil
group and 0.5 mg flumazenil group, respectively)(p＜0.001). The time to discharge after an examination was shorter in the flumazenil groups and showed dose-dependency (41.2±20.5 min, 22.1±10.9 min, 16.4±2.2 min for the control group, 0.25 mg flumazenil group and 0.5 mg flumazenil group, respectively) (p＜0.001). There was no significant difference in patient satisfaction among the three groups. The degree of memory recall was better in the 0.5 mg flumazenil group than in the other two groups (p＜0.001).
Conclusions: Flumazenil reversal of midazolam sedative endoscopy results in fast recovery and is helpful to minimize memory loss after an examination without interference of satisfaction. (Korean J Gastrointest
Endosc 2008;36:206-212)
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KEYWORD
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Flumazenil, Midazolam, Endoscopy
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